Symbol
Name
ID

Hfe
homeostatic iron regulator
MGI:109191

Phenotype annotations related to liver/biliary system

Darker colors indicate more annotations

Human Phenotypes

Elevated hepatic iron concentration

Hepatic steatosis

Portal hypertension

Hepatosplenomegaly

Hepatomegaly

Abnormality of the liver

Hepatic lobular inflammation

Cirrhosis

Micronodular cirrhosis

Hepatic fibrosis

Periportal fibrosis

Hepatocellular necrosis

Hepatitis

Chronic hepatitis

Viral hepatitis

Subacute progressive viral hepatitis

Cholelithiasis

Biliary cirrhosis

Cholangiocarcinoma

Cholestasis

Prolonged neonatal jaundice

Portal inflammation

Hepatocellular carcinoma

Disease(s) Associated with HFE

beta thalassemia

cystic fibrosis

hemochromatosis

hemochromatosis type 1

hepatocellular carcinoma

metabolic dysfunction-associated steatotic liver disease

myelofibrosis

porphyria cutanea tarda

Mouse Phenotypes		decreased liver iron level	increased liver iron level
Availability	Mouse Genotype	decreased liver iron level	increased liver iron level
	Hfe^tm1.1Jrco/Hfe^tm1.1Jrco
	Hfe^tm1.1Nca/Hfe^tm1.1Nca
	Hfe^tm1.1Wsr/Hfe^tm1.1Wsr
	Hfe^tm1Gfn/Hfe^tm1Gfn
	Hfe^tm1Sly/Hfe^tm1Sly
	Hfe^tm2Nca/Hfe^tm2Nca
	Hfe^tm2Nca/Hfe^tm2Nca Tg(Ttr-Hfe)1Nca/0
	Hfe^tm2Sly/Hfe^tm2Sly
	Hfe^tm3Sly/Hfe^tm3Sly
	Hfe^tm1Sly/Hfe^tm2Sly
	Hfe^tm2Nca/Hfe⁺
	Hfe^tm2Sly/Hfe^tm3Sly
	Hfe^tm1Wsr/Hfe^tm1Wsr Tg(Alb1-cre)7Gsc/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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